Taste is probably the least dangerous one to lose. You need sight to see the dangers around you, or see cool stuff. You need your hearing in case of something bad happening nearby that you can't see, something sneaking up on you, and just to be able to hear music. You need feeling for balance and knowing where to put your feet down, or if you're cutting/burning/whatever yourself (just because you can't feel it doesn't mean it's not effecting you.) Smell can help you to tell if there's a fire nearby, or some other hazard that has a scent. You can also often tell if something is bad to put in your mouth by smell (rotten foods, etc.)
So yeah, I'd go with taste. It'd really suck to not be able to taste anything ever again-eating food would be very boring-but that's about the only setback that I could think of. Anyhoo...
Wuv, Yer Mom
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