I would say some of the bosses I've fought in Resident Evil's take the cake. I think I've said this before but I didn't like that screaming ho in RE0. I think she's the one in a hanging coffin cage thing, and you have to let her out to get something. Then, later she chases you around this circular room.
For some reason she scared the bajeebies out of me more than any other freak in RE.
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