I'm suprized no ones said Radiata Stories yet. It has the funniest main character of any game ever period.
Leonard: "Yours it the bed over there." Jack: "Nooooooooo!"
Leonard: "When you're done with the death whales, come inside and get changed." Jack: "...K."

Also te first of these two boss fights are fricken hilarious.
YouTube - Radiata Stories - Gabriel Celesta Boss Fight
YouTube - Radiata Stories - Radian Boss Fight