I've only hit one of the hardest things to hit... pigeons.

I was driving back from something during the day, in a moderately urban area. In between two factories, there was a huge puddle with tons of pigeons just chillin and being stupid. I didn't want to hit them, so I slow down and honk. The area was dead enough so I didn't have to worry about even stopping. I honk once more and most of them scatter, then I go about doing my 30-35. Just as the last of them finally start to scatter, I wind up hitting 3. Two off the grill, which definitely died on impact and one that hit off the metal right next to my windshield. It popped up into the air and actually started to fly after me for a few seconds, until it plopped into the ground. If pigeons weren't so grimey, I might have felt bad, but seeing this one bird chase me while looking completely drunk was way too funny.

I've also almost hit a few deer (some of them are HUGE!) and I'm sure I squashed a frog or two in my time. Nothing more substantial than that though.