My mother went through a similar thing. She and my gran had an argument, and later on my gran asked her to come over to her house. She refused because she was still angry with my gran. That night, my gran died. My mom still hasn't gotten over it.
Also, I can relate to your feelings about your sister. Mine is of a similar sort.
If I could go back in time I would have rather gone and studied music and voice, to become a professional singer. However, if I had done that it is very likely I would never have met the love of my life, so in the end I think it's something I wish I could have gone back and done but if I were given the option of actually doing it, at the cost of losing my partner, I'd say no.
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