FFX is probably one of the more difficult ones due to some of the bosses and if you're not prepared for them they can very easily wipe a party. I'm guess you're talking about Sin. It's been a long time since I've played it, but if you use your summons as shields to take hits that will help you survive longer, as if they get killed nothing bad happens to the party. You still have to deal with it being out until you get back to healing it, but it is a small price for keeping the party alive against total party wipe attacks and such.
Usually going into bosses I would max out my overdrive and go in the fights with those off the bat. Making use of Tidus' quick hit will help you get a lot of hits in before it is the enemy's turn. But Yuna's overdrive with Summoning Bahamut will generally give you a good head start, since you'll be able to do a megaflare at the start and then if Bahamut survive long enough he probably can do a second before killed. Or you can just release him after doing the Megaflare and return to a normal party.
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