Borderlands 1 is at the top of my list for most beats. Have done 3 playthroughs as a Solider, 2 as a Siren, 2 as a Hunter, and then 2 as a Berserker. As you can tell by the extra playthrough the Solider was my favorite class, prolly why I immediately picked the Commando class in Borderlands 2.

The second most beats I have is on Final Fantasy Tactics. I think I have done like 7 play throughs on it. My first of second favorite final fantasy game ever.