And as far as Victor disappearing goes when you kill Mr House; it won't have any impact because killing House is part of a quest line for an independent Vegas, and the one who gives you the quests is Yes Man.
So...you can kill House if you want to. It won't do anything bad.
And House's penthouse doesn't have a bed anyways, I don't think. I haven't seen one.
Also if you help another faction and "have to kill House", well that makes sense. Because House is a faction in and of himself, so obviously you have to remove him as an obstacle. I mean, House wants to off everyone else, too.
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