Me, I've got myself a constant mana drain effect. The longer I go without sleep, the faster it drains. Gets kind of annoying at times, once I run out I go crash in a heap. Luckily I have a near endless supply various Mana restoration potions, Amp, Monster, Venom, Nuclear, and Nos to name a few. They also fortify my speed substats for a few hours, and increase twitchiness. THen of course I have Jack Daniel's around, that foritifies sarcasm, argessiveness, and humor for a while, but decreases hand-eye coordination, reaction time, and speeds up my mana drain, so I use it sparingly. Mainly for boss fights.