Without exaggeration, there are like millions of webcomics out there. I'm interested to hear/read which ones you guys read.

My personal favorite is Cyanide and Happiness. I have yet to read one made by Rob and not to giggle at least. When it comes to video games I usually turn to VG Cats (Super Effective has to be the best Pokemon parody to date), although new updates have been rather slow lately. Another favorite of mine is Virtual Shackles, love it's art style and great humor. Even though it's one of the most popular webcomics out there I never cared much to read Penny Arcade.